Evaluation of the effects of simulated hypoxia by CoCl 2 on radioresistance and change of hypoxia-inducible factors in human glioblastoma U87 tumor cell line.
Elham KhakshourMohammad Taghi Bahreyni-ToossiKazem AnvariMohammad Amin ShahramFereshteh Vaziri-NezamdoustHosein AzimianPublished in: Mutation research (2023)
can effectively increase hypoxia-associated genes, specially HIF-1α and GLUT-1, but did not affect HIF-2α gene expression. Also, it can increase the clearance of ROS, respectively, and it leads to inducing radioresistance of U87 cells.