Role of Dickkopf-3 in Blood Pressure Regulation in Mice and Hypertensive Rats.
Carla Letizia BuscetiAlbino CarrizzoFranca BianchiMassimiliano De LuciaAntonio DamatoChiara CazzinEleonora VenturiniPaola Di PietroRoxana Paula GinereteLuisa Di MennaMaria CotugnoRosita StanzioneSimona MarchittiSerena MigliarinoMichele CiccarelliSebastiano SciarrettaValeria BrunoGiuseppe BattagliaFrancesco FornaiMassimo VolpeSperanza RubattuFerdinando NicolettiCarmine VecchionePublished in: Circulation research (2023)
These findings demonstrate that Dkk3 acts as peripheral and central regulator of BP by promoting VEGF expression and activating a VEGF/Akt/eNOS hypotensive axis.
Keyphrases
- endothelial cells
- vascular endothelial growth factor
- blood pressure
- signaling pathway
- poor prognosis
- pi k akt
- cell proliferation
- high fat diet induced
- hypertensive patients
- transcription factor
- heart rate
- nitric oxide synthase
- type diabetes
- binding protein
- insulin resistance
- metabolic syndrome
- long non coding rna
- chemotherapy induced
- nitric oxide
- skeletal muscle
- weight loss