Clinical Value of Longitudinal Serum Neurofilament Light Chain in Prodromal Genetic Frontotemporal Dementia.
Lucia A A GianniniHarro SeelaarEmma L van der EndeJackie M PoosLize C JiskootElise G P DopperYolande A L PijnenburgEline A J WillemseLisa VermuntCharlotte E TeunissenJohn van SwietenLieke H MeeterPublished in: Neurology (2023)
NfL increase discriminates individuals who convert to prodromal FTD from those who do not, preceding significant frontotemporal MRI volume loss. However, NfL alone is limited in predicting the exact timing of prodromal conversion. NfL levels also vary depending on underlying variant-carrying genes and clinical phenotypes. These findings help to guide participant recruitment for clinical trials targeting prodromal genetic FTD.