Lasting s-ketamine block of spreading depolarizations in subarachnoid hemorrhage: a retrospective cohort study.

Edgar SantosArturo Olivares-RiveraSebastian MajorRenán Sánchez-PorrasLorenz UhlmannKevin KunzmannRoland ZerellesModar KentarVasilis KolaAdrian Hernández AguileraMildred Gutierrez HerreraColine L LemaleJohannes WoitzikJed A HartingsOliver W SakowitzAndreas W UnterbergJens P Dreier

Published in: Critical care (London, England) (2019)

These results provide a foundation for a multicenter, neuromonitoring-guided, proof-of-concept trial of ketamine and midazolam as a first-line sedative regime.

Keyphrases

subarachnoid hemorrhage
brain injury
cerebral ischemia
pain management
phase iii
study protocol
clinical trial
phase ii
double blind
cross sectional
chronic pain