PWWP2B Fine-Tunes Adipose Thermogenesis by Stabilizing HDACs in a NuRD Subcomplex.
Linyu YanWeiwei JinQingwen ZhaoXuan CuiTing ShiYingjiang XuFeiyan LiWenfang JinZhe ZhangZhao ZhangQi-Qun TangDong-Ning PanPublished in: Advanced science (Weinheim, Baden-Wurttemberg, Germany) (2021)
Histone deacetylases (HDACs) are widely involved in many biological processes, as well as in control of brown and beige adipose physiology, but the precise molecular mechanisms by which HDACs are assembled into transcriptional machinery to fine-tune thermogenic program remain ill-defined. PWWP domain containing 2b (PWWP2B), which is identified as a component of the nucleosome remodeling and deacetylation complex (NuRD), interacts and stabilizes HDAC1/2 at the thermogenic gene promoters to suppress their expression. Ablation of Pwwp2b promotes adipocyte thermogenesis and ameliorates diet-induced obesity in vivo. Intriguingly, Pwwp2b is not only a brown fat-enriched gene but also dramatically induced by cold and sympathetic stimulation, which may serve as a physiological brake to avoid over-activation of thermogenesis in brown and beige fat cells.
Keyphrases
- adipose tissue
- insulin resistance
- air pollution
- induced apoptosis
- copy number
- genome wide
- metabolic syndrome
- high fat diet induced
- poor prognosis
- type diabetes
- binding protein
- gene expression
- dna methylation
- weight loss
- cell cycle arrest
- transcription factor
- long non coding rna
- cell death
- body mass index
- endoplasmic reticulum stress
- physical activity