Visible-Light-Mediated ( sp 3 )Cα-H Functionalization of Ethers Enabled by Electron Donor-Acceptor Complex.

A synthetically beneficial visible-light-mediated protocol has been disclosed to achieve C-H amination of readily available feedstocks cyclic and acyclic ethers. A rarely identified N -bromosuccinamide-tetrahydrofuran electron donor-acceptor complex served as an initiator to functionalize both α-diazoketones and dialkyl azodicarboxylates. This developed methodology gives an alternative and milder way to construct the C-N bond and can be explored for the formation of C-C bond to perform arylation and allylation reactions.