Lupus susceptibility region containing CTLA4 rs17268364 functionally reduces CTLA4 expression by binding EWSR1 and correlates IFN-α signature.

Yuan-Yuan QiXin-Yu ZhaoXin-Ran LiuYan-Na WangYa-Ling ZhaiXiao-Xue ZhangXiao-Yang WangLi-Jie ZhangYa-Fei ZhaoYan CuiXiang-Hui NingXu-Jie Zhou

Published in: Arthritis research & therapy (2021)

The present study confirmed the functional role of rs17268364 in the CTLA4-ICOS intergenic region that increased SLE susceptibility in the Chinese population.

Keyphrases

systemic lupus erythematosus
disease activity
poor prognosis
immune response
binding protein
rheumatoid arthritis
long non coding rna
transcription factor