High concentration of estrogen resulted by COH may affect the secretion of pro-angiogenic factors in uNK cells by downregulating the expression of IL-11 in decidual stromal cells.

Hui MuHaikun YuSong YanJie LuJiaqin MaoDan SunNi JinZheng FangXueyan LuJie DongYing SuShuqiang ChenXiaohong Wang

Published in: Journal of assisted reproduction and genetics (2024)

These results suggested the downregulation of IL-11 expression in DSCs caused by high estrogen levels affects the secretion of pro-angiogenic factors in uNK cells, which provided an explanation for the pregnancy complications caused by COH.

Keyphrases

induced apoptosis
poor prognosis
cell cycle arrest
estrogen receptor
cell proliferation
endoplasmic reticulum stress
oxidative stress
binding protein
risk factors
pi k akt