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Molecular Pathology of Human Papilloma Virus-Negative Cervical Cancers.

Hiroshi YoshidaKouya ShiraishiTomoyasu Kato
Published in: Cancers (2021)
Cervical cancer is the fourth most common cancer in women worldwide and is predominantly caused by infection with human papillomavirus (HPV). However, a small subset of cervical cancers tests negative for HPV, including true HPV-independent cancers and false-negative cases. True HPV-negative cancers appear to be more prevalent in certain pathological adenocarcinoma subtypes, such as gastric- and clear-cell-type adenocarcinomas. Moreover, HPV-negative cervical cancers have proven to be a biologically distinct tumor subset that follows a different pathogenetic pathway to HPV-associated cervical cancers. HPV-negative cervical cancers are often diagnosed at an advanced stage with a poor prognosis and are expected to persist in the post-HPV vaccination era; therefore, it is important to understand HPV-negative cancers. In this review, we provide a concise overview of the molecular pathology of HPV-negative cervical cancers, with a focus on their definitions, the potential causes of false-negative HPV tests, and the histology, genetic profiles, and pathogenesis of HPV-negative cancers.
Keyphrases
  • high grade
  • cervical cancer screening
  • poor prognosis
  • endothelial cells
  • gene expression
  • type diabetes
  • polycystic ovary syndrome
  • genome wide
  • single molecule
  • human health