The role of microRNA-155 in glomerular endothelial cell injury induced by high glucose.
Kaiying HeZhan ChenJing ZhaoYang HeRongrong DengXin FanJianqin WangXiaochun ZhouPublished in: Molecular biology reports (2022)
MiR-155 can negatively regulate the expression of target gene ETS-1 and its downstream factors VCAM-1, MCP-1 and cleaved caspase-3, thus mediating the inflammatory response and apoptosis of HRGEC.
Keyphrases
- high glucose
- endothelial cells
- inflammatory response
- cell death
- poor prognosis
- long non coding rna
- cell proliferation
- endoplasmic reticulum stress
- cell cycle arrest
- transcription factor
- oxidative stress
- induced apoptosis
- lipopolysaccharide induced
- lps induced
- copy number
- long noncoding rna
- genome wide
- toll like receptor
- genome wide identification
- vascular endothelial growth factor
- binding protein
- cell adhesion
- immune response
- diabetic nephropathy