Clinical significance of long non-coding RNA ZEB2-AS1 and EMT-related markers in ductal and lobular breast cancer.

Mahboobeh Zarei Kianoosh Malekzadeh Mahmoud Omidi Mousavi Pegah

Published in: Cancer reports (Hoboken, N.J.) (2023)

Collectively, our findings suggest that ZEB2-AS1 expression is significantly upregulated in tumor tissues, especially in advanced stages and ZEB2-AS1 is associated with the aggressiveness of tumors by functioning as putative oncogenic lncRNA. In addition, a combination of ZEB2-AS1 and these EMT markers in breast cancer potentiates these genes as biomarkers for tumor progression.

Keyphrases

long non coding rna
poor prognosis
epithelial mesenchymal transition
genome wide
transcription factor
signaling pathway
binding protein