Relationship between villous atrophy and Wnt pathway gene expressions in pediatric celiac patients.

Metin Çalişkan Güzide Doğan Seda Orenay-Boyacioglu

Published in: Revista da Associacao Medica Brasileira (1992) (2023)

Wnt signaling in the early stages of the disease of Marsh 1-2 involves high expression of LRP5 and CXADR genes, while expression of these two genes reduces, and DVL2, CCND2, and NFATC1 gene expressions clearly increase with a transduction variation observed from Marsh 3a stage when villous atrophy begins to form. It appears that the Wnt pathway may contribute to disease progression through expression changes.

Keyphrases

poor prognosis
genome wide
genome wide identification
end stage renal disease
stem cells
chronic kidney disease
binding protein
long non coding rna
copy number
dna methylation
peritoneal dialysis
prognostic factors
gene expression
young adults