Determinants of pre-vaccination antibody responses to SARS-CoV-2: a population-based longitudinal study (COVIDENCE UK).
Mohammad TalaeiSian E FaustiniHayley HoltDavid A JolliffeGiulia VivaldiMatthew GreenigNatalia PerdekSheena MaltbyCarola M BigognoJane SymonsGwyneth A DaviesRonan A LyonsChristopher J GriffithsFrank KeeAziz SheikhAlex G RichterSeif O ShaheenAdrian R MartineauPublished in: BMC medicine (2022)
Higher alcohol consumption and lower light physical exercise represent new modifiable risk factors for SARS-CoV-2 infection. Recognised associations between South Asian ethnic origin and obesity and higher risk of SARS-CoV-2 seropositivity were independent of other sociodemographic, behavioural, nutritional, clinical, and pharmacological factors investigated. Among seropositive participants, higher titres of anti-Spike antibodies in people of South Asian ancestry and in obese people were not explained by greater COVID-19 disease severity in these groups.