Identification of amygdala-expressed genes associated with autism spectrum disorder.
Maria Jesus HerreroDmitry VelmeshevDavid Hernandez-PinedaSaarthak SethiShawn SorrellsPayal BanerjeeCatherine SullivanAbha R GuptaArnold R KriegsteinJoshua G CorbinPublished in: Molecular autism (2020)
Our pipeline narrows down the number of amygdala-expressed genes possibly involved in the social pathophysiology of ASD. Our human single-nucleus gene expression analyses revealed that ASD is characterized by changes in gene expression in specific cell types in the early postnatal amygdala.
Keyphrases
- autism spectrum disorder
- gene expression
- functional connectivity
- resting state
- attention deficit hyperactivity disorder
- intellectual disability
- prefrontal cortex
- dna methylation
- single cell
- temporal lobe epilepsy
- endothelial cells
- bioinformatics analysis
- genome wide
- healthcare
- mental health
- preterm infants
- cell therapy
- stress induced
- induced pluripotent stem cells
- stem cells
- pluripotent stem cells
- transcription factor