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Prognostic markers of DNA methylation and NGS sequencing in progressive glioblastoma from the EORTC-26101 trial.

Tobias KesslerDaniel SchrimpfLaura DörnerLing HaiLeon D KaulenJakob ItoMartin J Van Den BentMartin J B TaphoornAlba Ariela BrandesAhmed IdbaïhJulien DômontPaul M J ClementMario CamponeMartin BendszusAndreas von DeimlingFelix SahmMichael PlattenWolfgang WickAntje Wick
Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2023)
Thorough molecular classification is important for brain tumor clinical trial inclusion and evaluation. MGMT promoter methylation and RTK1 classifier assignment were prognostic in progressive glioblastoma. NF1 mutation may be a predictive biomarker for bevacizumab treatment.
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