Enhanced antigen cross-presentation in human colorectal cancer-associated fibroblasts through upregulation of the lysosomal protease cathepsin S.
Tom J HarryvanMarten VisserLinda de BruinLéonie PlugLisa GriffioenArend MulderPeter A van VeelenGerbrand J van der Heden van NoortMarlieke Lm JongsmaMiranda H MeeuwsenEmmanuel Jhj WiertzSaskia J A M SantegoetsJames Ch HardwickThorbald van HallJacques NeefjesSjoerd H Van der BurgLukas J A C HawinkelsElizabeth M E VerdegaalPublished in: Journal for immunotherapy of cancer (2022)
These data indicate that CAFs may directly suppress tumor-specific T cell function in an antigen-dependent fashion in human CRC.