Targeting Epsins to Inhibit Fibroblast Growth Factor Signaling While Potentiating Transforming Growth Factor-β Signaling Constrains Endothelial-to-Mesenchymal Transition in Atherosclerosis.
Yunzhou DongBeibei WangMulong DuBo ZhuKui CuiKathryn LiKe YuanDouglas B CowanSudarshan BhattacharjeeScott WongJin-Jun ShiDa-Zhi WangKaifu ChenJoyce BischoffMacRae F LintonHong ChenPublished in: Circulation (2023)
We conclude that epsins potentiate EndoMT during atherogenesis by increasing transforming growth factor-β signaling through fibroblast growth factor receptor-1 internalization and degradation. Inhibition of EndoMT by reducing epsin-fibroblast growth factor receptor-1 interaction with a therapeutic peptide may represent a novel treatment strategy for atherosclerosis.