Exosomes from cervical cancer cells facilitate pro-angiogenic endothelial reconditioning through transfer of Hedgehog-GLI signaling components.
Anjali BhatJoni YadavKulbhushan ThakurNikita AggarwalTanya TripathiArun ChhokarTejveer SinghMohit JadliAlok Chandra BhartiPublished in: Cancer cell international (2021)
Overall, the data showed cervical cancer exosomes promote pro-angiogenic response in endothelial cells via upregulation of Hh-GLI signaling and modulate downstream angiogenesis-related target genes. The study provides a novel exosome-mediated mechanism potentially favoring cervical angiogenesis and thus identifies the exosomes as potential pharmacological targets against locally-advanced metastatic cervical lesions.
Keyphrases
- endothelial cells
- mesenchymal stem cells
- stem cells
- squamous cell carcinoma
- locally advanced
- vascular endothelial growth factor
- high glucose
- genome wide
- induced apoptosis
- anti inflammatory
- small cell lung cancer
- cell cycle arrest
- rectal cancer
- neoadjuvant chemotherapy
- poor prognosis
- electronic health record
- signaling pathway
- radiation therapy
- endoplasmic reticulum stress
- big data
- risk assessment
- cell death
- lymph node
- machine learning
- clinical trial
- wound healing
- climate change
- drug induced