Association of Vascular Risk Factors and Cerebrovascular Pathology With Alzheimer Disease Pathologic Changes in Individuals Without Dementia.
Luigi LorenziniAlessio MaranzanoSilvia IngalaLyduine E CollijMario TranfaKaj BlennowCarol Di PerriChristopher FoleyNick C FoxGiovanni Battista FrisoniSven HallerPablo Martinez-LageDaisy MollisonJohn O'BrienPierre PayouxCraig W RitchiePhilip ScheltensAdam J SchwarzCarole Helene SudreBetty M TijmsFederico VerdeNicola TicozziVincenzo SilaniPieter Jelle VisserAdam WaldmanRobin WolzGaëlle ChételatMichael EwersAlle Meije WinkHenk-Jan Mm MutsaertsJuan-Domingo GispertJoanna Marguerite WardlawFrederik BarkhofPublished in: Neurology (2024)
and affects downstream neurodegeneration and cognitive impairment. We provide evidence of VRFs indirectly affecting the pathogenesis of AD, highlighting the importance of considering cSVD burden in memory clinics for AD risk evaluation and as an early window for intervention. These results stress the role of VRFs and cerebrovascular pathology as key biomarkers for accurate design of anti-amyloid clinical trials and offer new perspectives for patient stratification.