Hemodynamics of paradoxical severe aortic stenosis: insight from a pressure-volume loop analysis.
Michael GotzmannSabine HauptmannMaximilian HogewegDinah S ChoudhuryFabian SchiedatJohannes W DietrichTimm H WesthoffMartin BergbauerAndreas MüggePublished in: Clinical research in cardiology : official journal of the German Cardiac Society (2019)
The present study suggests that the hemodynamics of PLFLG AS can be explained by two mechanisms: (1) stiffness of the small left ventricle with reduced contractility, and (2) increased afterload due to the impairment of vascular function. Both mechanisms have similarities to those of heart failure with preserved EF. This type of remodeling may explain the poor prognosis of PLFLG AS.
Keyphrases
- poor prognosis
- aortic stenosis
- heart failure
- long non coding rna
- transcatheter aortic valve replacement
- ejection fraction
- left ventricular
- aortic valve replacement
- transcatheter aortic valve implantation
- aortic valve
- pulmonary hypertension
- early onset
- mitral valve
- coronary artery disease
- pulmonary artery
- transcription factor
- coronary artery