The association of miR-204 and mir-483 5p expression with clinicopathological features of Wilms tumor: Could this provide foresight?
Aylin Orgen ÇallıGizem IssinIsmail YilmazDilek InceErsin TuralIsmail GuzelisRefik Emre CecenHatice Nur OlgunDeniz GokcayErdener OzerPublished in: Japanese journal of clinical oncology (2023)
The results of our study indicate that the relative expression levels of microRNA-204 in Wilms tumor tissues were significantly lower than that in adjacent normal tissues. By contrast, tumor tissue had a higher microRNA-483-5p expression than the corresponding normal tissues. A statistically significant difference between microRNA-204 expression level with age and the presence of anaplasia was observed. The upregulation of microRNA-483-5p was found to have a significant correlation with patients after preoperative chemotherapy and complete tumor necrosis. Taken together, our data suggest that microRNA-204 could play a critical role as a tumor suppressor, whereas microRNA-483-5p acts as an oncogene in Wilms tumor progression. More importantly, microRNA-204 might be a novel predictive biomarker for anaplastic histology and could be useful for developing therapeutic interventions targeting this marker.
Keyphrases
- poor prognosis
- long non coding rna
- gene expression
- cell proliferation
- end stage renal disease
- binding protein
- magnetic resonance
- ejection fraction
- physical activity
- chronic kidney disease
- patients undergoing
- computed tomography
- signaling pathway
- prognostic factors
- peritoneal dialysis
- patient reported outcomes
- locally advanced
- artificial intelligence