Polygenic Determinants for Subsequent Breast Cancer Risk in Survivors of Childhood Cancer: The St Jude Lifetime Cohort Study (SJLIFE).

Zhaoming WangQi LiuCarmen L WilsonJohn EastonHeather MulderTi-Cheng ChangMichael C Rusch Michael N EdmonsonStephen V RiceMatthew J EhrhardtRebecca M HowellChimene A KesserwanGang WuKim E NicholsJames R DowningMelissa M HudsonJinghui ZhangYutaka YasuiLeslie L Robison

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2018)

Genetic profiles comprised of small-effect common variants and large-effect predisposing mutations can inform personalized breast cancer risk and surveillance/intervention in female childhood cancer survivors.

Keyphrases

breast cancer risk
childhood cancer
young adults
randomized controlled trial
public health
copy number
gene expression
genome wide