Interferon-Gamma test for the detection of Mycobacterium tuberculosis complex infection in Macaca mulatta and other non-human primates.
JoAnn L YeeKamm ProngayBrodie MilesJeremy SmedleyScott G HansenMichael K AxthelmAmir ArdeshirKoen K A Van RompayGregory TimmelJeffrey A RobertsPublished in: Journal of medical primatology (2019)
We have formatted an assay to detect Mycobacterium tuberculosis complex infections of non-human primates. Commercially available reagents were used to elicit a specific immune response that was measured by interferon-gamma release. Initial evaluation using blood samples from Rhesus macaques experimentally infected with M tuberculosis distinguished infected versus uninfected animals.