Immunologic Characterization and T cell Receptor Repertoires of Expanded Tumor-infiltrating Lymphocytes in Patients with Renal Cell Carcinoma.
Moon Hee LeeJason TheodoropoulosJani HuuhtanenDipabarna BhattacharyaPetrus JärvinenSara TornbergHarry NísenTuomas K MirttiIlona UskiAnita KumariKarita PeltonenArianna DraghiMarco DoniaAnna KreutzmanMohamed El MissiryPublished in: Cancer research communications (2023)
TILs are a heterogenous group of immune cells that recognize and attack the tumor, thus are utilized in various clinical trials. In our study, we explored the TILs in patients with kidney cancer by expanding the TILs using a clinical-grade protocol, as well as observed their characteristics and ability to recognize the tumor using in-depth experimental and computational tools.