Gliomatosis cerebri in children: A poor prognostic phenotype of diffuse gliomas with a distinct molecular profile.
Gunther NussbaumerMartin BeneschYura GrabovskaAlan MackayDavid CastelJacques GrillMarta M AlonsoManila AntonelliSimon BaileyJoshua N BaughVeronica BiassoniMirjam Blattner JohnsonAlberto BroniscerAndrea CaraiGiovanna Stefania ColafatiNiclas ColditzSelim CorbaciogluShauna CrampsieNatacha Entz-WerleMatthias EyrichLea L FrikerMichael C FrühwaldMaria Luisa GarrèNicolas U GerberFelice GiangasperoMaria J Gil-da-CostaNorbert GrafDarren HargravePeter HauserUlrich HerrlingerMarion HoffmannEsther HullemanElisa IzquierdoSandra JacobsMichael KarremannAntonis KattamisRejin KebudiRolf-Dieter KortmannRobert KwiecienMaura MassiminoAngela MastronuzziEvelina MieleGiovanni MoranaClaudia M NoackVirve PentikainenThomas PerweinStefan M PfisterTorsten PietschKleoniki RokaSabrina RossiStefan RutkowskiElisabetta SchiavelloClemens SeidelJaroslav ŠtěrbaDominik SturmDavid SumerauerAnna TackeSara TemelsoChiara ValentiniDannis van VuurdenPascale VarletSophie E M Veldhuijzen van ZantenMaria VinciAndré O von BuerenMonika Warmuth-MetzPieter WesselingMaria WieseJohannes E A WolffJosef ZamecnikAndrés Morales La MadridBrigitte BisonGerrit H GielenDavid T W JonesChris JonesChristof M KrammPublished in: Neuro-oncology (2024)
Contrary to previous studies, our representative pediatric GC study provides evidence that GC has a strong predilection to arise on the background of specific molecular features (especially pedHGG_RTK2, pedHGG_A/B, EGFR and BCOR mutations, chromosome 6 rearrangements).