Blockade of macrophage-associated programmed death 1 inhibits the pyroptosis signalling pathway in sepsis.

Yang FuDenian WangShuang WangQi ZhangHao LiuShanshan YangYanming XuBinwu Ying

Published in: Inflammation research : official journal of the European Histamine Research Society ... [et al.] (2021)

Our results suggested that intermediate monocytes with high expression of PD-1 may be involved in the progression of sepsis. PD-1 might play a critical role in regulating the pyroptosis signalling pathway in sepsis.

Keyphrases

septic shock
acute kidney injury
intensive care unit
nlrp inflammasome
poor prognosis
adipose tissue
immune response
peripheral blood
long non coding rna
binding protein