Differential expression of Tim-3, PD-1, and CCR5 on peripheral T and B lymphocytes in hepatitis C virus-related hepatocellular carcinoma and their impact on treatment outcomes.

Asmaa M ZahranHelal F HettaAmal RayanAbeer Sharaf EldinElham Ahmed HassanHussein FakhryAhmed SolimanOmnia El-Badawy

Published in: Cancer immunology, immunotherapy : CII (2020)

Modulation of the expression of immune checkpoints as Tim-3 and PD-1, and of CCR5 on T cells is somehow related to HCC. CD8+ T cells expressing PD-1 were the most relevant to HCC prognosis (OS and treatment response) and could represent a promising target for immune therapy against HCC. Future studies need to focus on exploring PD-1+ B cells and Tim-3+CD4+ cells, which seem to play a significant role in the pathogenesis of HCC.

Keyphrases

hepatitis c virus
dendritic cells
induced apoptosis
poor prognosis
regulatory t cells
human immunodeficiency virus
peripheral blood
current status
oxidative stress
signaling pathway
cell death
smoking cessation
case control
antiretroviral therapy