A rapid functional decline type of amyotrophic lateral sclerosis is linked to low expression of TTN.

Hazuki WatanabeNaoki AtsutaAkihiro HirakawaRyoichi NakamuraMasahiro NakatochiShinsuke IshigakiAritoshi IidaShiro IkegawaMichiaki KuboDaichi YokoiHirohisa WatanabeMizuki ItoMasahisa KatsunoYuishin IzumiMitsuya MoritaKazuaki KanaiAkira TaniguchiIkuko AibaKoji AbeKoichi MizoguchiMasaya OdaOsamu KanoKoichi OkamotoSatoshi KuwabaraKazuko HasegawaTakashi ImaiAkihiro KawataMasashi AokiShoji TsujiKenji NakashimaRyuji KajiGen Sobue

Published in: Journal of neurology, neurosurgery, and psychiatry (2016)

We detected an LD block associated with a rapid functional decline in patients with sporadic ALS, which is linked to decreased expression of TTN.

Keyphrases

amyotrophic lateral sclerosis
poor prognosis
binding protein
long non coding rna
late onset
quantum dots