Effect of Flavonoid-Coated Gold Nanoparticles on Bacterial Colonization in Mice Organs.
Sundus RiazNosheen Fatima RanaIrshad HussainTahreem TanweerAfrah NawazFarid MenaaHussnain A JanjuaTahseen AlamAmna BatoolAyesha NaeemMaryam HameedSyed Mohsin AliPublished in: Nanomaterials (Basel, Switzerland) (2020)
Multidrug resistance (MDR) has been a potentiator for the exploration of antibiotics. Nano drug delivery systems have opened new avenues to overcome this challenge. Although antibacterial nanocarriers are extensively realized, their effect on the bacteria residing inside the tissues and their toxicity is rarely explored. This study investigated the effects of flavonoid coated gold nanoparticles (FAuNPs) on the colonization of Enterococcus faecalis in the mouse liver and kidneys. Flavonoids were extracted from the leaves of Berberis lycium Royle and used to stabilize gold following a green synthesis approach. FAuNPs were characterized by ultraviolet-visible (UV-Vis) spectroscopy, Fourier-transform infrared spectroscopy (FTIR), scanning transmission electron microscopy (STEM), X-ray powder diffraction (XRD), and energy-dispersive X-ray spectroscopy (EDS). FAuNPs showed significantly higher reduction in bacterial counts in in-vitro and in-vivo in mice organs as compared to the free flavonoids owing to their biocompatibility and effectiveness.
Keyphrases
- electron microscopy
- gold nanoparticles
- high resolution
- multidrug resistant
- high fat diet induced
- single molecule
- reduced graphene oxide
- randomized controlled trial
- drug delivery
- systematic review
- gene expression
- silver nanoparticles
- oxidative stress
- ionic liquid
- gas chromatography mass spectrometry
- wild type
- metabolic syndrome
- cancer therapy
- adipose tissue
- solid phase extraction
- type diabetes
- insulin resistance
- drug release
- computed tomography
- aqueous solution