The effect of diabetes mellitus on differentiation of mesenchymal stem cells into insulin-producing cells.
Omar I BadrMohamed M KamalShohda A El-MaraghyHeba R GhaiadPublished in: Biological research (2024)
Our findings reveal the effectiveness of N-Ad-MSCs in differentiating into IPCs in vitro and controlling the hyperglycemia of STZ-induced diabetic rats in vivo compared to DM-Ad-MSCs.
Keyphrases
- diabetic rats
- mesenchymal stem cells
- oxidative stress
- umbilical cord
- induced apoptosis
- glycemic control
- type diabetes
- bone marrow
- cell cycle arrest
- randomized controlled trial
- cell therapy
- genome wide
- stem cells
- endoplasmic reticulum stress
- signaling pathway
- adipose tissue
- gene expression
- cell proliferation
- metabolic syndrome
- cell death
- contrast enhanced
- computed tomography
- pi k akt