The significance of long non-coding RNAs in the pathogenesis, diagnosis and treatment of inflammatory bowel disease.
Fei JiangMin WuRongpeng LiPublished in: Precision clinical medicine (2023)
Inflammatory bowel diseases (IBD) are a group of chronic relapsing gastrointestinal inflammatory diseases with significant global incidence. Although the pathomechanism of IBD has been extensively investigated, several aspects of its pathogenesis remain unclear. Long non-coding RNAs (lncRNAs) are transcripts with more than 200 nucleotides in length that have potential protein-coding functions. LncRNAs play important roles in biological processes such as epigenetic modification, transcriptional regulation and post-transcriptional regulation. In this review, we summarize recent advances in research on IBD-related lncRNAs from the perspective of the overall intestinal microenvironment, as well as their potential roles as immune regulators, diagnostic biomarkers and therapeutic targets or agents for IBD.
Keyphrases
- long non coding rna
- poor prognosis
- ulcerative colitis
- multiple sclerosis
- network analysis
- stem cells
- dna methylation
- gene expression
- multidrug resistant
- genome wide identification
- genome wide analysis
- transcription factor
- oxidative stress
- risk factors
- human health
- rheumatoid arthritis
- drug induced
- atomic force microscopy
- disease activity
- high resolution
- climate change