Altered Expression of EMT-Related Factors Snail, Wnt4, and Notch2 in the Short-Term Streptozotocin-Induced Diabetic Rat Kidneys.
Matea Dragun JurićAnita RacetinNatalija FilipovicNela KelamSandra KostićDragan LjutićKatarina VukojevićPublished in: Life (Basel, Switzerland) (2022)
The obtained results point to the EMT-related factors Snail, Wnt4, and Notch2 as a potential contributor to diabetic nephropathy development and progression. Changes in their expression, especially in PCT and DCT, could serve as diagnostic biomarkers for the early stages of DM and might be a promising novel therapeutic target in this condition.