Nucleolin-Sle A Glycoforms as E-Selectin Ligands and Potentially Targetable Biomarkers at the Cell Surface of Gastric Cancer Cells.

Elisabete FernandesRui FreitasDylan FerreiraJanine SoaresRita AzevedoCristiana GaiteiroAndreia PeixotoSara OliveiraSofia CottonMarta Relvas-SantosLuis Pedro AfonsoCarlos PalmeiraMaria José OliveiraRita FerreiraAndré M N SilvaLúcio Lara SantosJosé Alexandre Ferreira

Published in: Cancers (2020)

NCL-SLeA is a biomarker of poor prognosis in GC holding potential for precise cancer targeting. This is the first report describing SLeA in preferentially nuclear protein, setting a new paradigm for cancer biomarkers discovery and targeted therapies.

Keyphrases

poor prognosis
papillary thyroid
cell surface
long non coding rna
squamous cell
systemic lupus erythematosus
lymph node metastasis
high throughput
rheumatoid arthritis
childhood cancer
risk assessment
protein protein
cancer therapy
drug delivery
solid phase extraction