miR-92b-3p protects retinal tissues against DNA damage and apoptosis by targeting BTG2 in experimental myopia.
Jinpeng LiuBo BaoTuling LiZhaohui YangYongle DuRuixue ZhangJizhao XinJiawen HaoGuimin WangHongsheng BiDadong GuoPublished in: Journal of translational medicine (2024)
In conclusion, p53 and BTG2 were activated in the retinal tissue of myopic guinea pigs, and the activated BTG2 could elevate the expression of CDK2 and BAX, and attenuate the expression of BCL-2, which in turn promote apoptosis and eventually lead to retinal thinning and impaired visual function in myopic guinea pigs. The miR-92b-3p intravitreal injection can attenuate the elongation of ocular length and retinal thickness, and inhibit the CDK2, BAX, and p53 expression by targeting BTG2, thereby ameliorating DNA damage and apoptosis in LIM guinea pigs and protecting ocular tissues.
Keyphrases
- optical coherence tomography
- dna damage
- optic nerve
- oxidative stress
- diabetic retinopathy
- poor prognosis
- endoplasmic reticulum stress
- cell cycle arrest
- cell death
- induced apoptosis
- cell cycle
- gene expression
- long non coding rna
- cell proliferation
- vascular endothelial growth factor
- fluorescent probe
- sensitive detection
- living cells