Human Milk Oligosaccharides Protect against Necrotizing Enterocolitis by Activating Intestinal Cell Differentiation.

Bo Li Richard You WuRachael G HorneAbdalla AhmedDorothy LeeShaiya C RobinsonHaitao ZhuCarol LeeMarissa CadeteKathene C Johnson-HenryEva LandbergMashriq AlganabiThomas AbrahamssonPaul Delgado-OlguinAgostino PierroPhilip M Sherman

Published in: Molecular nutrition & food research (2020)

These findings demonstrate HMOs protect against NEC in part by altering the differentiation of the crypt-villus axis. In addition, this study suggests that pooled HMOs directly induce a series of biological processes, which provide mechanistic insights to how HMOs protect the host intestine.

Keyphrases

human milk
low birth weight
preterm infants
signaling pathway
preterm birth
randomized controlled trial
study protocol