Early diagnosis is associated with improved clinical outcomes in benign esophageal perforation: an individual patient data meta-analysis.

Bram D VermeulenBritt van der LeedenJawad T AliTomas GudbjartssonMichael HermanssonDonald E LowDouglas G AdlerAbraham J BothaXavier B D'JournoAtila ErogluLorenzo E FerriChristoph GublerJan Willem HavemanLileswar KamanRichard A KozarekSimon LawGunnar LoskeJoerg LindenmannJung-Hoon ParkJ David RichardsonPaulina SalminenHo-Yong SongJon A SøreideManon C W SpaanderJeffrey N TarascioJon A TsaiTim VanuytselCamiel RosmanPeter D Siersemanull null

Published in: Surgical endoscopy (2020)

This individual patient data meta-analysis confirms the general opinion that an early (≤ 24 h) compared to a late diagnosis (> 24 h) in benign esophageal perforations, particularly in IEP, is associated with improved clinical outcome.

Keyphrases

systematic review
meta analyses
case report
electronic health record
big data
case control
randomized controlled trial
machine learning