Deficiency of Transcription Factor Sp1 Contributes to Hypertrophic Cardiomyopathy.
Fulei ZhangHuixing ZhouJinfeng XueYuemei ZhangLiping ZhouJunwei LengGuojian FangYuanyuan LiuYan WangHongyu LiuYahan WuLingbin QiRan DuanXiaoyu HeYan WangYi LiuLi LiJian YangDandan LiangYi-Han ChenPublished in: Circulation research (2024)
Our study demonstrates that SP1 deficiency leads to HCM. SP1 overexpression exhibits significant therapeutic effects on both HCM mice and HCM hiPSC-CMs, suggesting that SP1 could be a potential intervention target for HCM.