Retrospective and integrative analyses of molecular characteristics and their specific imaging parameters in pediatric grade 1 gliomas.

Marie CoutantBenoit LhermitteAmelia-Naomie SaboAgathe ChammasDamien ReitaConsuelo SebastiaValérie DouzalFlaviu GaborAlexandra SalmonMarie-Pierre ChenardJulien TodeschiAndres CocaMarie-Amelie HengFlorence VincentNatacha Entz-Werlé

Published in: Pediatric blood & cancer (2022)

So, additionally to the presence of BRAF p.V600E or CDKN2A deletion in grade 1 PLGGs, the absence on diagnostic MRI of cystic parts and/or cystic conversion at 6-month chemotherapy were significantly linked to a worst prognosis and response to treatment. These imaging features should be considered as prognostic markers in future PLGG studies.

Keyphrases

high resolution
magnetic resonance imaging
high grade
cross sectional
computed tomography
squamous cell carcinoma
magnetic resonance
single molecule