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Using electronic health records to inform trial feasibility in a rare autoimmune blistering skin disease in England.

M S M PerssonK E HarmanK S ThomasJ R ChalmersY VinogradovaS M LanganJ Hippisley-CoxSonia Gran
Published in: BMC medical research methodology (2021)
Routinely collected electronic health records can be used to inform the feasibility of clinical trials in rare diseases, such as whether recruitment is feasible nationally and how long recruitment might take to meet recruitment targets. Future trials of bullous pemphigoid in England may use the data presented to inform trial design, including eligibility criteria and consent processes for enrolling people with dementia.
Keyphrases
  • electronic health record
  • clinical trial
  • phase iii
  • phase ii
  • clinical decision support
  • study protocol
  • adverse drug
  • open label
  • multiple sclerosis
  • randomized controlled trial
  • soft tissue
  • current status
  • data analysis