Piperaquine induced QTc prolongation decreases with repeated monthly dihydroartemisinin-piperaquine dosing in pregnant Ugandan women.

Emma HughesErika K WallenderRichard KajubiPrasanna JagannathanTeddy OchiengAbel KakuruMoses R KamyaTamara D ClarkPhilip J RosenthalGrant DorseyFrancesca AweekaRadojka M Savic

Published in: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America (2021)

Repeated DHA-PQ dosing did not result in an increased risk of QTc prolongation and the post-dose QTc intervals progressively decreased. Monthly dosing of DHA-PQ in pregnant women carries minimal risk of QTc prolongation.

Keyphrases

pregnant women
drug induced
pregnancy outcomes
fatty acid
drug administration
diabetic rats
polycystic ovary syndrome
adipose tissue
type diabetes
metabolic syndrome
insulin resistance
cervical cancer screening
stress induced
breast cancer risk