Critical roles of sphingosine kinase 1 in the regulation of neuroinflammation and neuronal injury after spinal cord injury.
Chenjian WangTianzhen XuBrittany Bolduc LachanceXiqiang ZhongGuangjie ShenTao XuChengxuan TangXiaofeng JiaPublished in: Journal of neuroinflammation (2021)
Our results demonstrate a critical role of Sphk1 in the post-traumatic SCI inflammatory cascade and present the Sphk1/S1P/S1PR3 axis as a potential target for therapeutic intervention to control neuroinflammation, relieve neuronal damage, and improve functional outcomes in SCI.
Keyphrases
- cerebral ischemia
- spinal cord injury
- lipopolysaccharide induced
- subarachnoid hemorrhage
- oxidative stress
- traumatic brain injury
- lps induced
- randomized controlled trial
- blood brain barrier
- cognitive impairment
- brain injury
- inflammatory response
- protein kinase
- tyrosine kinase
- human health
- risk assessment
- climate change