Autoinhibitory module underlies species difference in shear activation of von Willebrand factor.

Nicholas A Arce Yi Liu Wenchun Chen Xiaohui Frank Zhang Renhao Li

Published in: Journal of thrombosis and haemostasis : JTH (2022)

Our results suggest that the regulation of VWF-GPIbα binding has been specifically tuned to work optimally in different rheological architectures. Differences in the AIM sequence may contribute to the difference in VWF shear response between human and mice.

Keyphrases

endothelial cells
high fat diet induced
pluripotent stem cells
type diabetes
dna binding
metabolic syndrome
adipose tissue
binding protein
skeletal muscle