Donor-specific antibodies are associated with micro- and macrovascular coronary disease, restrictive myocardial damage, and poor outcome in heart-transplanted patients.

Tor Skibsted ClemmensenPernille Koefoed-NielsenLis-Ann JensenSteen Hvitfeldt PoulsenNiels Ramsing HolmBrian Bridal LøgstrupEvald Høj ChristiansenJouke DijkstraKamilla Pernille Bjerre ValenHans Eiskjaer

Published in: Clinical transplantation (2017)

DSA-positive patients had higher vasculopathy burden, higher filling pressures, and lower longitudinal myocardial deformation than DSA-negative patients. The DSA presence was a strong MACE predictor.

Keyphrases

end stage renal disease
ejection fraction
newly diagnosed
chronic kidney disease
coronary artery disease
oxidative stress
patient reported outcomes
risk factors
cross sectional
aortic stenosis
patient reported
transcatheter aortic valve replacement