Impact of mineralocorticoid receptor antagonists on the risk of sudden cardiac death in patients with heart failure and left-ventricular systolic dysfunction: an individual patient-level meta-analysis of three randomized-controlled trials.
Xavier RosselloCono AritiStuart J PocockJoão Pedro FerreiraNicolas GirerdJohn J V McMurrayDirk J Van VeldhuisenBertram PittFaiez ZannadPublished in: Clinical research in cardiology : official journal of the German Cardiac Society (2018)
MRAs reduce the risk for SCD by 23% in patients with heart failure and LVSD. In these patients, the use of MRAs, on top of other evidence-based medications, should be optimized. It might be useful to re-assess the benefit of implantable cardiac defibrillator (ICD) placement, as ICD treatment effect was evaluated in trials enrolling patients not receiving MRAs.