Discovery of alantolactone as a naturally occurring NLRP3 inhibitor to alleviate NLRP3-driven inflammatory diseases in mice.
Weifeng LiHaowen XuJingjing ShaoJiahao ChenYimin LinZhiwei ZhengYi WangWu LuoGuang LiangPublished in: British journal of pharmacology (2023)
The phytochemical alantolactone inhibited activity of NLRP3 inflammasomes by directly targeting the NACHT domain of NLRP3. Alantolactone shows great potential in the treatment of NLRP3-driven diseases and could lead to the development of novel NLRP3 inhibitors.