Guang Liang

ORCID

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 80

Top Venues

Journal of medicinal chemistry

Circulation research

British journal of pharmacology

Clinical and translational medicine

Wenzhou Medical University

This page only lists publications with an associated author ORCID identifier.

Affiliation History

Wenzhou Medical University Oct 01 2013

China

Professor :: School of Pharmaceutical Sciences

Publications

Chenchen Qian, Weiwei Zhu, Jiong Wang, Zhe Wang, Weiyang Tang, Xin Liu, Bo Jin, Yong Xu, Yuyang Zhang, Guang Liang, Yi Wang
Cyclic-di-GMP induces inflammation and acute lung injury through direct binding to MD2. Clinical and translational medicine 14 (8) (2024)
Ying Zhao, Shijie Fan, Hong Zhu, Qingqing Zhao, Zimin Fang, Diyun Xu, Wante Lin, Liming Lin, Xiang Hu, Gaojun Wu, Julian Min, Guang Liang
Podocyte OTUD5 alleviates diabetic kidney disease through deubiquitinating TAK1 and reducing podocyte inflammation and injury. Nature communications 15 (1) (2024)
Chenchen Qian, Weiwei Zhu, Jiong Wang, Zhe Wang, Weiyang Tang, Xin Liu, Bo Jin, Yong Xu, Yuyang Zhang, Guang Liang, Yi Wang
Cyclic-di-GMP induces inflammation and acute lung injury through direct binding to MD2. Clinical and translational medicine 14 (8) (2024)
Yu Zou, Xiemin Wang, Pan Chen, Zhiwei Zheng, Xiaobo Li, Zhichao Chen, Mi Guo, Ying Zhou, Chenhui Sun, Ran Wang, Wufu Zhu, Pengwu Zheng, Won-Jea Cho, Young-Chang Cho, Guang Liang, Qidong Tang
Fragment-Based Anti-inflammatory Agent Design and Target Identification: Discovery of AF-45 as an IRAK4 Inhibitor to Treat Ulcerative Colitis and Acute Lung Injury. Journal of medicinal chemistry 67 (13) (2024)
Yu Zou, Xiemin Wang, Pan Chen, Zhiwei Zheng, Xiaobo Li, Zhichao Chen, Mi Guo, Ying Zhou, Chenhui Sun, Ran Wang, Wufu Zhu, Pengwu Zheng, Won-Jea Cho, Young-Chang Cho, Guang Liang, Qidong Tang
Fragment-Based Anti-inflammatory Agent Design and Target Identification: Discovery of AF-45 as an IRAK4 Inhibitor to Treat Ulcerative Colitis and Acute Lung Injury. Journal of medicinal chemistry (2024)
Lintao Wang, Wu Luo, Suya Zhang, Junsheng Zhang, Lu He, Yifan Shi, Li Gao, Baochuan Wu, Xiaoyan Nie, Chenghong Hu, Xue Han, Chaoyong He, Biao Xu, Guang Liang
Macrophage-derived FGFR1 drives atherosclerosis through PLCγ-mediated activation of NF-κB inflammatory signaling pathway. Cardiovascular research (2024)
Sujuan Shuai, Jianyou Mao, Fan Zhou, Qifeng Yan, Lingfeng Chen, Jie Li, Patrick J Walsh, Guang Liang
Base-Promoted Synthesis of Isoquinolines through a Tandem Reaction of 2-Methyl-arylaldehydes and Nitriles. The Journal of organic chemistry 89 (10) (2024)
Sujuan Shuai, Jianyou Mao, Fan Zhou, Qifeng Yan, Lingfeng Chen, Jie Li, Patrick J Walsh, Guang Liang
Base-Promoted Synthesis of Isoquinolines through a Tandem Reaction of 2-Methyl-arylaldehydes and Nitriles. The Journal of organic chemistry (2024)
Ying Zhao, Shijie Fan, Hong Zhu, Qingqing Zhao, Zimin Fang, Diyun Xu, Wante Lin, Liming Lin, Xiang Hu, Gaojun Wu, Julian Min, Guang Liang
Podocyte OTUD5 alleviates diabetic kidney disease through deubiquitinating TAK1 and reducing podocyte inflammation and injury. Nature communications 15 (1) (2024)
Yu Zou, Xiemin Wang, Pan Chen, Zhiwei Zheng, Xiaobo Li, Zhichao Chen, Mi Guo, Ying Zhou, Chenhui Sun, Ran Wang, Wufu Zhu, Pengwu Zheng, Won-Jea Cho, Young-Chang Cho, Guang Liang, Qidong Tang
Fragment-Based Anti-inflammatory Agent Design and Target Identification: Discovery of AF-45 as an IRAK4 Inhibitor to Treat Ulcerative Colitis and Acute Lung Injury. Journal of medicinal chemistry 67 (13) (2024)
Ying Zhao, Shijie Fan, Hong Zhu, Qingqing Zhao, Zimin Fang, Diyun Xu, Wante Lin, Liming Lin, Xiang Hu, Gaojun Wu, Julian Min, Guang Liang
Podocyte OTUD5 alleviates diabetic kidney disease through deubiquitinating TAK1 and reducing podocyte inflammation and injury. Nature communications 15 (1) (2024)
Ying Zhao, Shijie Fan, Hong Zhu, Qingqing Zhao, Zimin Fang, Diyun Xu, Wante Lin, Liming Lin, Xiang Hu, Gaojun Wu, Julian Min, Guang Liang
Podocyte OTUD5 alleviates diabetic kidney disease through deubiquitinating TAK1 and reducing podocyte inflammation and injury. Nature communications 15 (1) (2024)
Jinfu Qian, Qinyan Wang, Jiachen Xu, Shiqi Liang, Qingsong Zheng, Xiaocheng Guo, Wu Luo, Weijian Huang, Xiaohong Long, Julian Min, Yi Wang, Gaojun Wu, Guang Liang
Macrophage OTUD1-CARD9 axis drives isoproterenol-induced inflammatory heart remodelling. Clinical and translational medicine 14 (8) (2024)
Yu Zou, Xiemin Wang, Pan Chen, Zhiwei Zheng, Xiaobo Li, Zhichao Chen, Mi Guo, Ying Zhou, Chenhui Sun, Ran Wang, Wufu Zhu, Pengwu Zheng, Won-Jea Cho, Young-Chang Cho, Guang Liang, Qidong Tang
Fragment-Based Anti-inflammatory Agent Design and Target Identification: Discovery of AF-45 as an IRAK4 Inhibitor to Treat Ulcerative Colitis and Acute Lung Injury. Journal of medicinal chemistry (2024)
Jinfu Qian, Qinyan Wang, Jiachen Xu, Shiqi Liang, Qingsong Zheng, Xiaocheng Guo, Wu Luo, Weijian Huang, Xiaohong Long, Julian Min, Yi Wang, Gaojun Wu, Guang Liang
Macrophage OTUD1-CARD9 axis drives isoproterenol-induced inflammatory heart remodelling. Clinical and translational medicine 14 (8) (2024)
Xue Han, Jiajia Wei, Ruyi Zheng, Yu Tu, Mengyang Wang, Lingfeng Chen, Zheng Xu, Lei Zheng, Chao Zheng, Qiaojuan Shi, Huazhong Ying, Guang Liang
Macrophage SHP2 Deficiency Alleviates Diabetic Nephropathy via Suppression of MAPK/NF-κB- Dependent Inflammation. Diabetes 73 (5) (2024)
Lingfeng Chen, Ruixiang Luo, Lin Ma, Ying Xu, Jiaqi Cao, Zheng Jiang, Shiyan Chen, Xiaohao Huang, Mingwan Zhang, Lei Zheng, Yawen Zhang, Lina Yin, Jie Yu, Xiaochun Zheng, Lulu Zheng, Ping Huang, Guang Liang
Discovery of LC-MI-3: A Potent and Orally Bioavailable Degrader of Interleukin-1 Receptor-Associated Kinase 4 for the Treatment of Inflammatory Diseases. Journal of medicinal chemistry 67 (10) (2024)
Jinfu Qian, Qinyan Wang, Jiachen Xu, Shiqi Liang, Qingsong Zheng, Xiaocheng Guo, Wu Luo, Weijian Huang, Xiaohong Long, Julian Min, Yi Wang, Gaojun Wu, Guang Liang
Macrophage OTUD1-CARD9 axis drives isoproterenol-induced inflammatory heart remodelling. Clinical and translational medicine 14 (8) (2024)
Lingfeng Chen, Ruixiang Luo, Lin Ma, Ying Xu, Jiaqi Cao, Zheng Jiang, Shiyan Chen, Xiaohao Huang, Mingwan Zhang, Lei Zheng, Yawen Zhang, Lina Yin, Jie Yu, Xiaochun Zheng, Lulu Zheng, Ping Huang, Guang Liang
Discovery of LC-MI-3: A Potent and Orally Bioavailable Degrader of Interleukin-1 Receptor-Associated Kinase 4 for the Treatment of Inflammatory Diseases. Journal of medicinal chemistry (2024)
Xue Han, Jiajia Wei, Ruyi Zheng, Yu Tu, Mengyang Wang, Lingfeng Chen, Zheng Xu, Lei Zheng, Chao Zheng, Qiaojuan Shi, Huazhong Ying, Guang Liang
Macrophage SHP2 Deficiency Alleviates Diabetic Nephropathy via Suppression of MAPK/NF-κB- Dependent Inflammation. Diabetes 73 (5) (2024)
Weifeng Li, Haowen Xu, Jingjing Shao, Jiahao Chen, Yimin Lin, Zhiwei Zheng, Yi Wang, Wu Luo, Guang Liang
Discovery of alantolactone as a naturally occurring NLRP3 inhibitor to alleviate NLRP3-driven inflammatory diseases in mice. British journal of pharmacology (2023)
Weifeng Li, Haowen Xu, Jingjing Shao, Jiahao Chen, Yimin Lin, Zhiwei Zheng, Yi Wang, Wu Luo, Guang Liang
Discovery of alantolactone as a natural NLRP3 inhibitor to alleviate NLRP3-driven inflammatory diseases in mice. British journal of pharmacology (2023)
Bin Yang, Yunjie Zhao, Wu Luo, Weiwei Zhu, Leiming Jin, Minxiu Wang, Lin Ye, Yi Wang, Guang Liang
Macrophage DCLK1 promotes obesity-induced cardiomyopathy via activating RIP2/TAK1 signaling pathway. Cell death & disease 14 (7) (2023)
Pan Chen, Ying Zhou, Xiaobo Li, Jun Yang, Zhiwei Zheng, Yu Zou, Xiang Li, Jing Liao, Jintian Dai, Yuye Xu, Lina Yin, Gaozhi Chen, Jing Gu, Qin Ouyang, Won-Jea Cho, Qidong Tang, Guang Liang
Design, Synthesis, and Bioevaluation of Novel MyD88 Inhibitor c17 against Acute Lung Injury Derived from the Virtual Screen. Journal of medicinal chemistry (2023)
Bozhi Ye, Hao Zhou, Yanghao Chen, Wu Luo, Wante Lin, Ying Zhao, Jibo Han, Xue Han, Wei-Jian Huang, Gaojun Wu, Xu Wang, Guang Liang
USP25 Ameliorates Pathological Cardiac Hypertrophy by Stabilizing SERCA2a in Cardiomyocytes. Circulation research 132 (4) (2023)
Bozhi Ye, Hao Zhou, Yanghao Chen, Wu Luo, Wante Lin, Ying Zhao, Jibo Han, Xue Han, Wei-Jian Huang, Gaojun Wu, Xu Wang, Guang Liang
USP25 Ameliorates Pathological Cardiac Hypertrophy by Stabilizing SERCA2a in Cardiomyocytes. Circulation research 132 (4) (2023)
Jibo Han, Zimin Fang, Bingjiang Han, Bozhi Ye, Wante Lin, Yucheng Jiang, Xue Han, Xu Wang, Gaojun Wu, Yi Wang, Guang Liang
Deubiquitinase JOSD2 improves calcium handling and attenuates cardiac hypertrophy and dysfunction by stabilizing SERCA2a in cardiomyocytes. Nature cardiovascular research 2 (8) (2023)
Xiaoyu Sun, Shuhong Chen, Ying Zhao, Tong Wu, Zheyu Zhao, Wu Luo, Jibo Han, Zimin Fang, Bozhi Ye, Gang Cao, Shengbin Huang, Guang Liang
OTUD6A in tubular epithelial cells mediates angiotensin II-induced kidney injury by targeting STAT3. American journal of physiology. Cell physiology 326 (2) (2023)
Bozhi Ye, Hao Zhou, Yanghao Chen, Wu Luo, Wante Lin, Ying Zhao, Jibo Han, Xue Han, Wei-Jian Huang, Gaojun Wu, Xu Wang, Guang Liang
USP25 Ameliorates Pathological Cardiac Hypertrophy by Stabilizing SERCA2a in Cardiomyocytes. Circulation research (2023)
Xiaoyu Sun, Shuhong Chen, Ying Zhao, Tong Wu, Zheyu Zhao, Wu Luo, Jibo Han, Zimin Fang, Bozhi Ye, Gang Cao, Shengbin Huang, Guang Liang
OTUD6A in tubular epithelial cells mediates angiotensin II-induced kidney injury by targeting STAT3. American journal of physiology. Cell physiology 326 (2) (2023)
Bozhi Ye, Hao Zhou, Yanghao Chen, Wu Luo, Wante Lin, Ying Zhao, Jibo Han, Xue Han, Wei-Jian Huang, Gaojun Wu, Xu Wang, Guang Liang
USP25 Ameliorates Pathological Cardiac Hypertrophy by Stabilizing SERCA2a in Cardiomyocytes. Circulation research 132 (4) (2023)
Wu Luo, Yiyi Jin, Yuchen Jiang, Libin Yang, Haowen Xu, Di Wu, Yanmei Zhang, Lina Yin, Zia Ali Khan, Guang Liang, Yi Wang
Doublecortin-like kinase 1 activates NF-κB to induce inflammatory responses by binding directly to IKKβ. Cell death and differentiation (2023)
Bozhi Ye, Hao Zhou, Yanghao Chen, Wu Luo, Wante Lin, Ying Zhao, Jibo Han, Xue Han, Wei-Jian Huang, Gaojun Wu, Xu Wang, Guang Liang
USP25 Ameliorates Pathological Cardiac Hypertrophy by Stabilizing SERCA2a in Cardiomyocytes. Circulation research 132 (4) (2023)
Shiju Ye, He Huang, Xue Han, Wu Luo, Lili Wu, Yang Ye, Yingchao Gong, Xia Zhao, Wei-Jian Huang, Yi Wang, Xiaohong Long, Guo-Sheng Fu, Guang Liang
Dectin-1 Acts as a Non-Classical Receptor of Ang II to Induce Cardiac Remodeling. Circulation research 132 (6) (2023)
Shiju Ye, He Huang, Xue Han, Wu Luo, Lili Wu, Yang Ye, Yingchao Gong, Xia Zhao, Wei-Jian Huang, Yi Wang, Xiaohong Long, Guo-Sheng Fu, Guang Liang
Dectin-1 Acts as a Non-Classical Receptor of Ang II to Induce Cardiac Remodeling. Circulation research (2023)
Zhuqi Huang, Sirui Shen, Xue Han, Weixin Li, Wu Luo, Liming Lin, Mingjiang Xu, Yi Wang, Weijian Huang, Gaojun Wu, Guang Liang
Macrophage DCLK1 promotes atherosclerosis via binding to IKKβ and inducing inflammatory responses. EMBO molecular medicine (2023)
Lingfeng Chen, Lili Fu, Jingchuan Sun, Zhiqiang Huang, Mingzhen Fang, Allen Zinkle, Xin Liu, Junliang Lu, Zixiang Pan, Yang Wang, Guang Liang, Xiaokun Li, Gaozhi Chen, Moosa Mohammadi
Structural basis for FGF hormone signalling. Nature (2023)
Jing Liao, Jun Yang, Xiaobo Li, Chenghong Hu, Weiwei Zhu, Ying Zhou, Yu Zou, Mi Guo, Zhichao Chen, Xiang Li, Jintian Dai, Yuye Xu, Zhiwei Zheng, Pan Chen, Won-Jea Cho, Guang Liang, Qidong Tang
Discovery of the Diphenyl 6-Oxo-1,6-dihydropyridazine-3-carboxylate/carboxamide Analogue J27 for the Treatment of Acute Lung Injury and Sepsis by Targeting JNK2 and Inhibiting the JNK2-NF-κB/MAPK Pathway. Journal of medicinal chemistry (2023)
Xin Liu, Yi Fang, Xinting Lv, Chenghong Hu, Guorong Chen, Lingxi Zhang, Bo Jin, Lijiang Huang, Wu Luo, Guang Liang, Yi Wang
Deubiquitinase OTUD6A in macrophages promotes intestinal inflammation and colitis via deubiquitination of NLRP3. Cell death and differentiation (2023)
Bozhi Ye, Hao Zhou, Yanghao Chen, Wu Luo, Wante Lin, Ying Zhao, Jibo Han, Xue Han, Wei-Jian Huang, Gaojun Wu, Xu Wang, Guang Liang
USP25 Ameliorates Pathological Cardiac Hypertrophy by Stabilizing SERCA2a in Cardiomyocytes. Circulation research 132 (4) (2023)
Shiju Ye, He Huang, Xue Han, Wu Luo, Lili Wu, Yang Ye, Yingchao Gong, Xia Zhao, Wei-Jian Huang, Yi Wang, Xiaohong Long, Guo-Sheng Fu, Guang Liang
Dectin-1 Acts as a Non-Classical Receptor of Ang II to Induce Cardiac Remodeling. Circulation research 132 (6) (2023)
Zhuqi Huang, Sirui Shen, Mengyang Wang, Weixin Li, Gaojun Wu, Weijian Huang, Wu Luo, Guang Liang
Mouse endothelial OTUD1 promotes angiotensin II-induced vascular remodeling by deubiquitinating SMAD3. EMBO reports 24 (3) (2022)
Wu Luo, Lin Ye, Xue-Ting Hu, Mei-Hong Wang, Min-Xiu Wang, Lei-Ming Jin, Zhong-Xiang Xiao, Jian-Chang Qian, Yi Wang, Wei Zuo, Li-Jiang Huang, Guang Liang
MD2 deficiency prevents high-fat diet-induced AMPK suppression and lipid accumulation through regulating TBK1 in non-alcoholic fatty liver disease. Clinical and translational medicine 12 (3) (2022)
Zhuqi Huang, Sirui Shen, Mengyang Wang, Weixin Li, Gaojun Wu, Weijian Huang, Wu Luo, Guang Liang
Mouse endothelial OTUD1 promotes angiotensin II-induced vascular remodeling by deubiquitinating SMAD3. EMBO reports (2022)
Yanghao Chen, Wante Lin, Pan Chen, Bozhi Ye, Wu Luo, Xu Wang, Weijian Huang, Gaojun Wu, Guang Liang
Tabersonine alleviates obesity-induced cardiomyopathy by binding to Transforming growth factor activated kinase 1 (TAK1) and inhibiting TAK1-mediated inflammation. Phytotherapy research : PTR (2022)
Na Yang, Chunpeng Zou, Wu Luo, Diyun Xu, Mengyang Wang, Yi Wang, Gaojun Wu, Peiren Shan, Guang Liang
Sclareol attenuates angiotensin II-induced cardiac remodeling and inflammation via inhibiting MAPK signaling. Phytotherapy research : PTR (2022)
Jie Li, Huan Wang, Huimin Jin, Zhenhua Xiang, Lingfeng Chen, Patrick J Walsh, Guang Liang
Base-Promoted Tandem Synthesis of 3,4-Dihydroisoquinolones. Organic letters 24 (44) (2022)
Wu Luo, Ke Lin, Junyi Hua, Jibo Han, Qiuyan Zhang, Lingfeng Chen, Zia A Khan, Gaojun Wu, Yi Wang, Guang Liang
Schisandrin B Attenuates Diabetic Cardiomyopathy by Targeting MyD88 and Inhibiting MyD88-Dependent Inflammation. Advanced science (Weinheim, Baden-Wurttemberg, Germany) 9 (31) (2022)
Zheng Xu, Wu Luo, Lingfeng Chen, Zaishou Zhuang, Daona Yang, Jianchang Qian, Zia A Khan, Xinfu Guan, Yi Wang, Xiaokun Li, Guang Liang
Ang II (Angiotensin II)-Induced FGFR1 (Fibroblast Growth Factor Receptor 1) Activation in Tubular Epithelial Cells Promotes Hypertensive Kidney Fibrosis and Injury. Hypertension (Dallas, Tex. : 1979) 79 (9) (2022)
Hongjin Chen, Yuchen Jiang, Rongdiao Liu, Jie Deng, Qinbo Chen, Lingfeng Chen, Guang Liang, Xiong Chen, Zheng Xu
Curcumin Derivative C66 Suppresses Pancreatic Cancer Progression through the Inhibition of JNK-Mediated Inflammation. Molecules (Basel, Switzerland) 27 (10) (2022)
Xue Han, Jiajia Zhang, Li Zhou, Jiajia Wei, Yu Tu, Qiaojuan Shi, Yi Zhang, Juan Ren, Yi Wang, Huazhong Ying, Guang Liang
Sclareol ameliorates hyperglycemia-induced renal injury through inhibiting the MAPK/NF-κB signaling pathway. Phytotherapy research : PTR 36 (6) (2022)
Zhuqi Huang, Sirui Shen, Mengyang Wang, Weixin Li, Gaojun Wu, Weijian Huang, Wu Luo, Guang Liang
Mouse endothelial OTUD1 promotes angiotensin II-induced vascular remodeling by deubiquitinating SMAD3. EMBO reports 24 (3) (2022)
Xi Chen, Ying Zhao, Xu Wang, Yimin Lin, Weixin Zhao, Di Wu, Jingye Pan, Wu Luo, Yi Wang, Guang Liang
FAK mediates LPS-induced inflammatory lung injury through interacting TAK1 and activating TAK1-NFκB pathway. Cell death & disease 13 (7) (2022)
Yanghao Chen, Wante Lin, Lingfeng Zhong, Zimin Fang, Bozhi Ye, Zhe Wang, Nipon Chattipakorn, Weijian Huang, Guang Liang, Gaojun Wu
Bicyclol Attenuates Obesity-Induced Cardiomyopathy via Inhibiting NF-κB and MAPK Signaling Pathways. Cardiovascular drugs and therapy (2022)
Weiwei Zhu, Minxiu Wang, Leiming Jin, Bin Yang, Bin Bai, Rumbidzai Natasha Mutsinze, Wei Zuo, Siriporn C Chattipakorn, Joo Young Huh, Guang Liang, Yi Wang
Licochalcone A protects against LPS-induced inflammation and acute lung injury by directly binding with MD2. British journal of pharmacology (2022)
Zhuqi Huang, Sirui Shen, Mengyang Wang, Weixin Li, Gaojun Wu, Weijian Huang, Wu Luo, Guang Liang
Mouse endothelial OTUD1 promotes angiotensin II-induced vascular remodeling by deubiquitinating SMAD3. EMBO reports 24 (3) (2022)
Zhuqi Huang, Sirui Shen, Mengyang Wang, Weixin Li, Gaojun Wu, Weijian Huang, Wu Luo, Guang Liang
Mouse endothelial OTUD1 promotes angiotensin II-induced vascular remodeling by deubiquitinating SMAD3. EMBO reports 24 (3) (2022)
Jianqiang Chen, Xiangxiang Jin, Yanan Mei, Zhe Shen, Jufan Zhu, Hongyi Shi, Minshan Wang, Xiaohui Zheng, Guang Liang
The different biological effects of TMPyP4 and cisplatin in the inflammatory microenvironment of osteosarcoma are attributed to G-quadruplex. Cell proliferation 54 (9) (2021)
Lingfeng Chen, Yanmei Zhang, Lina Yin, Binhao Cai, Ping Huang, Xiaokun Li, Guang Liang
Fibroblast growth factor receptor fusions in cancer: opportunities and challenges. Journal of experimental & clinical cancer research : CR 40 (1) (2021)
Dezhong Wang, Yuan Yin, Shuyi Wang, Tianyang Zhao, Fanghua Gong, Yushuo Zhao, Beibei Wang, Yuli Huang, Zizhao Cheng, Guanghui Zhu, Zengshou Wang, Yang Wang, Jun Ren, Guang Liang, Xiaokun Li, Zhifeng Huang
FGF1ΔHBS prevents diabetic cardiomyopathy by maintaining mitochondrial homeostasis and reducing oxidative stress via AMPK/Nur77 suppression. Signal transduction and targeted therapy 6 (1) (2021)
Fang Xu, Yuxiang Ma, Wei Huang, Jian Gao, Mengmeng Guo, Jianxin Li, Lingdong Kong, Guang Liang, Ronghui Du, Qiang Xu, Xudong Wu
Typically inhibiting USP14 promotes autophagy in M1-like macrophages and alleviates CLP-induced sepsis. Cell death & disease 11 (8) (2020)
Lingfeng Chen, Lulu Zheng, Pengqin Chen, Guang Liang
Myeloid Differentiation Primary Response Protein 88 (MyD88): The Central Hub of TLR/IL-1R Signaling. Journal of medicinal chemistry 63 (22) (2020)
Hui He, Jie Guo, Wei Sun, Bin Yang, Fengzhi Zhang, Guang Liang
Palladium-Catalyzed Direct Mono- or Polyhalogenation of Benzothiadiazole Derivatives. The Journal of organic chemistry 85 (5) (2020)
Xu Wang, Victor Antony, Yi Wang, Gaojun Wu, Guang Liang
Pattern recognition receptor-mediated inflammation in diabetic vascular complications. Medicinal research reviews 40 (6) (2020)
Yan Zhou, Hong Liang, Yaoguang Sheng, Shaoli Wang, Yi Gao, Lingling Zhan, Zhilong Zheng, Mengjie Yang, Guang Liang, Jianmin Zhou, Jun Deng, Zengqiang Song
Ruthenium(II)-Catalyzed C-H Activation of Chromones with Maleimides to Synthesize Succinimide/Maleimide-Containing Chromones. The Journal of organic chemistry 85 (14) (2020)
Yi Wang, Wu Luo, Jibo Han, Zia A Khan, Qilu Fang, Yiyi Jin, Xuemei Chen, Yali Zhang, Meihong Wang, Jianchang Qian, Weijian Huang, Hazel Lum, Gaojun Wu, Guang Liang
MD2 activation by direct AGE interaction drives inflammatory diabetic cardiomyopathy. Nature communications 11 (1) (2020)
Changtian Yin, Xuanxuan Dai, Xiangjie Huang, Wangyu Zhu, Xi Chen, Qiulin Zhou, Canwei Wang, Chengguang Zhao, Peng Zou, Guang Liang, Vinothkumar Rajamanickam, Ouchen Wang, Xiaohua Zhang, Ri Cui
Alantolactone promotes ER stress-mediated apoptosis by inhibition of TrxR1 in triple-negative breast cancer cell lines and in a mouse model. Journal of cellular and molecular medicine 23 (3) (2019)
Zhiguo Liu, Lingfeng Chen, Pengtian Yu, Yali Zhang, Bo Fang, Chao Wu, Wu Luo, Xianxin Chen, Chenglong Li, Guang Liang
Discovery of 3-(Indol-5-yl)-indazole Derivatives as Novel Myeloid Differentiation Protein 2/Toll-like Receptor 4 Antagonists for Treatment of Acute Lung Injury. Journal of medicinal chemistry 62 (11) (2019)
Yi Wang, Qilu Fang, Yiyi Jin, Zhoudi Liu, Chunpeng Zou, Weihui Yu, Weixin Li, Xiaoou Shan, Ruijie Chen, Zia Khan, Guang Liang
Blockade of myeloid differentiation 2 attenuates diabetic nephropathy by reducing activation of the renin-angiotensin system in mouse kidneys. British journal of pharmacology 176 (14) (2019)
Zheng Xu, Chunpeng Zou, Weihui Yu, Sujing Xu, Lan Huang, Zia Khan, Jingying Wang, Guang Liang, Yi Wang
Inhibition of STAT3 activation mediated by toll-like receptor 4 attenuates angiotensin II-induced renal fibrosis and dysfunction. British journal of pharmacology 176 (14) (2019)
Hailun Zheng, Lehe Yang, Yanting Kang, Min Chen, Shichong Lin, Youqun Xiang, Caleb Li, Xuanxuan Dai, Xiaoying Huang, Guang Liang, Chengguang Zhao
Alantolactone sensitizes human pancreatic cancer cells to EGFR inhibitors through the inhibition of STAT3 signaling. Molecular carcinogenesis 58 (4) (2019)
Shengban You, Jianchang Qian, Chuchu Sun, Hailing Zhang, Shiju Ye, Taiwei Chen, Zheng Xu, Jingying Wang, Weijian Huang, Guang Liang
An Aza resveratrol-chalcone derivative 6b protects mice against diabetic cardiomyopathy by alleviating inflammation and oxidative stress. Journal of cellular and molecular medicine 22 (3) (2018)
Yiyi Jin, Jianchang Qian, Xin Ju, Xiaodong Bao, Li Li, Suqing Zheng, Xiong Chen, Zhongxiang Xiao, Xuemei Chen, Weiwei Zhu, Weixin Li, Wencan Wu, Guang Liang
Osthole Protects against Acute Lung Injury by Suppressing NF-κB-Dependent Inflammation. Mediators of inflammation 2018 (2018)
Zhen Wang, Yali Zhang, Daniel M Pinkas, Alice E Fox, Jinfeng Luo, Huocong Huang, Shengyang Cui, Qiuping Xiang, Tingting Xu, Qiuju Xun, Dongsheng Zhu, Zhengchao Tu, Xiaomei Ren, Rolf A Brekken, Alex N Bullock, Guang Liang, Ke Ding, Xiaoyun Lu
Design, Synthesis, and Biological Evaluation of 3-(Imidazo[1,2- a]pyrazin-3-ylethynyl)-4-isopropyl- N-(3-((4-methylpiperazin-1-yl)methyl)-5-(trifluoromethyl)phenyl)benzamide as a Dual Inhibitor of Discoidin Domain Receptors 1 and 2. Journal of medicinal chemistry 61 (17) (2018)
Yali Zhang, Tingting Xu, Zheer Pan, Xiangting Ge, Chuchu Sun, Chun Lu, Hongjin Chen, Zhongxiang Xiao, Bing Zhang, Yuanrong Dai, Guang Liang
Shikonin inhibits myeloid differentiation protein 2 to prevent LPS-induced acute lung injury. British journal of pharmacology 175 (5) (2018)
Chen Feng, Yiqun Xia, Peng Zou, Miaoshan Shen, Jie Hu, Shilong Ying, Jialing Pan, Zhiguo Liu, Xuanxuan Dai, Weishan Zhuge, Guang Liang, Yeping Ruan
Curcumin analog L48H37 induces apoptosis through ROS-mediated endoplasmic reticulum stress and STAT3 pathways in human lung cancer cells. Molecular carcinogenesis 56 (7) (2017)
Lingfeng Chen, Weitao Fu, Lulu Zheng, Zhiguo Liu, Guang Liang
Recent Progress of Small-Molecule Epidermal Growth Factor Receptor (EGFR) Inhibitors against C797S Resistance in Non-Small-Cell Lung Cancer. Journal of medicinal chemistry 61 (10) (2017)
Qilu Fang, Lintao Wang, Daona Yang, Xiong Chen, Xiaoou Shan, Yali Zhang, Hazel Lum, Jingying Wang, Peng Zhong, Guang Liang, Yi Wang
Blockade of myeloid differentiation protein 2 prevents obesity-induced inflammation and nephropathy. Journal of cellular and molecular medicine 21 (12) (2017)
Lintao Wang, Jibo Han, Peiren Shan, Shengban You, Xuemei Chen, Yiyi Jin, Jingying Wang, Weijian Huang, Yi Wang, Guang Liang
MD2 Blockage Protects Obesity-Induced Vascular Remodeling via Activating AMPK/Nrf2. Obesity (Silver Spring, Md.) 25 (9) (2017)
Yali Zhang, Beibei Wu, Hailing Zhang, Xiangting Ge, Shilong Ying, Mengwei Hu, Weixin Li, Yi Huang, Li Wang, Chao Chen, Xiaoou Shan, Guang Liang
Inhibition of MD2-dependent inflammation attenuates the progression of non-alcoholic fatty liver disease. Journal of cellular and molecular medicine 22 (2) (2017)

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