Long-term outcomes of induction chemotherapy followed by chemoradiotherapy vs chemoradiotherapy alone as treatment of unresectable head and neck cancer: follow-up of the Spanish Head and Neck Cancer Group (TTCC) 2503 Trial.
R HittL IglesiasA López-PousaA Berrocal-JaimeJ J GrauC García-GirónJ Martínez-TruferoM GuixJ Lambea-SorrosalE Del Barco-MorilloX León-VintróA J Cunquero-TomasN BasteA OcañaJuan Jesús Cruz Hernándeznull nullPublished in: Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico (2020)
After a long follow-up, the TTCC 2503 trial failed to show the benefit of IC-CRT in unresectable LAHNSCC regarding the primary end point. However, fit patients with ECOG 0 and primary larynx-hypopharyngeal tumors may benefit from the use of IC if administered by an experienced team. ClinicalTrials.gov identifier NCT00261703.