Identifying exposition to low oxygen environment in human macrophages using secondary ion mass spectrometry and multivariate analysis.
Magali CourtJean-Paul BarnesArnaud MilletPublished in: Rapid communications in mass spectrometry : RCM (2018)
Our study demonstrates that macrophage molecular signature to low oxygen environment is dependent on their polarization. TOF-SIMS shows the clear capability to produce species revealing this exposition. This result opens the way to the use of TOF-SIMS as a tool to explore hypoxia in human tissues.