Immune related proteins and tumor infiltrating CD8+ lymphocytes in hypopharyngeal cancer in relation to human papillomavirus (HPV) and clinical outcome.
David LandinAndreas Ährlund-RichterLeila MirzaieMichael MintsAnders NäsmanAeneas KolevLinda MarklundTina DalianisEva Munck-WiklandTorbjörn RamqvistPublished in: Head & neck (2020)
High expression of immune proteins in HPV-positive HPSCC may explain the better clinical outcome. CD8+ TILs are of relevance for outcome of HPV-negative HPSCC, while tumors with high immune activity but poor patient survival suggest a role for immune therapy.