APOE3 - R136S mutation confers resilience against tau pathology via cGAS-STING-IFN inhibition.

Sarah NaguibEileen Ruth TorresChloe Lopez-LeeLi FanMaitreyee BhagwatKendra NormanSe-In LeeJingjie ZhuPearly YeMan Ying WongTark PatelSue-Ann MokWenjie LuoSubhash C SinhaMingrui ZhaoShiaoching GongLi Gan

Published in: bioRxiv : the preprint server for biology (2024)

The R136S mutation on APOE3 enhances resistance to tau-related disease processes by downregulating the cGAS-STING-IFN signaling pathway.

Keyphrases

signaling pathway
cognitive decline
dendritic cells
immune response
cerebrospinal fluid
high fat diet
pi k akt
climate change
social support
oxidative stress
metabolic syndrome
cell proliferation